Design and Biological Evaluation of Transition Metal–Schiff Base Complexes Against Multidrug-Resistant Microorganisms
Keywords:
Schiff base complexes, Transition metals, Multidrug-resistant microorganisms, Antimicrobial activity, Coordination chemistry, Metal complexes, Minimum inhibitory concentration (MIC), Drug resistance.Abstract
The emergence of multidrug-resistant (MDR) microorganisms has become a major global health concern, necessitating the development of novel antimicrobial agents with enhanced efficacy. This study focuses on the design, synthesis, and biological evaluation of transition metal–Schiff base complexes derived from a biologically active Schiff base ligand. Complexes of Cu(II), Co(II), Ni(II), Zn(II), and Fe(III) were synthesized and characterized using spectroscopic and physicochemical techniques, including FT-IR, UV–Visible spectroscopy, elemental analysis, and magnetic susceptibility measurements. The antimicrobial potential of the synthesized compounds was evaluated against selected MDR bacterial and fungal strains using agar well diffusion and minimum inhibitory concentration (MIC) assays. The metal complexes exhibited significantly higher antimicrobial activity than the free Schiff base ligand, with the Cu(II) complex demonstrating the strongest inhibitory effect. These findings suggest that transition metal–Schiff base complexes are promising candidates for developing new antimicrobial agents against drug-resistant pathogens.
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