Investigation Of Hepatoprotective Potential on Glycyrrhiza Glabra LINNN
Keywords:
Hepatoprotective, Histopathology, Anti-inflammatoryAbstract
The present study investigates the hepatoprotective potential of Glycyrrhiza glabra Linn. (commonly known as licorice), a medicinal plant extensively recognized for its therapeutic applications in traditional medicine systems. The objective was to evaluate its capacity to protect hepatic tissue from damage induced by oxidative stress and hepatotoxins. Plant extracts of Glycyrrhiza glabra were prepared and subjected to comprehensive phytochemical screening, which confirmed the presence of bioactive constituents such as glycyrrhizin, flavonoids, and saponins—compounds well-documented for their antioxidant and anti-inflammatory activities. Histopathological assessments demonstrated notable restoration of normal liver architecture in treated experimental groups compared to the toxin-induced control group, indicating significant protective efficacy. Furthermore, in vitro assays conducted on hepatic cell lines corroborated these results, revealing a marked reduction in cellular injury. This protective effect is attributed to the modulation of oxidative stress pathways, suggesting that Glycyrrhiza glabra mitigates hepatocellular damage through its free radical–scavenging and anti-inflammatory mechanisms. These findings support the potential use of Glycyrrhiza glabra as a natural hepatoprotective agent, warranting further investigation for its possible integration into therapeutic strategies against liver disorders.
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