Assessment Of Adverse Drug Reaction Patterns and Their Associated Risk Factors in Clinical Pharmacotherapy
DOI:
https://doi.org/10.64882/ijrt.v14.i3.1872Keywords:
Medication safety, Pharmacovigilance, Polypharmacy, Clinical pharmacotherapy, Adverse drug reactionsAbstract
Clinical pharmacotherapy and can influence medication safety and effectiveness. The current research investigated ADR patterns and their risk factors in patients receiving pharmacotherapy. An observational study was performed during six months involving 150 patients. ADRs were characterized based on clinical pattern, involved therapeutic class, causality, severity and preventability of the reactions, while patient-related and therapy-related risk factors were statistically analyzed. Out of 150 patients, 36 (24.0%) suffered from ADRs with the total number of 45 ADR occurrences reported. The most common type of adverse drug reaction was gastrointestinal reaction (26.7%), neurological (20.0%) and dermatological reactions (17.8%). The most frequently implicated therapeutic classes were antimicrobial drugs (24.4%), cardiovascular (20.0%) and antidiabetic drugs (15.6%). The majority of ADRs was classified as mild and moderate, and 40.0% of ADRs were definitely or probably preventable. Multiple regression analysis revealed that polypharmacy was an independent risk factor of ADR occurrence, whereas patient's age was another significant factor affecting the risk of ADRs.
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